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WikiProject iconVital articles: Level 5 / Biology C‑class
WikiProject iconLeucine has been listed as a level-5 vital article in Biology (General). If you can improve it, please do.
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Is it vital that bodybuilder's supplement with Leucine  ?

While not "vital," I've heard that it aids in the transport and overall intake of protein to the muscles.


The "LALALALALA" at the end of the article leads me to believe this page was vandalized. If so, please restore any information that may have been altered or removed.


Can anyone add a link or a section on leucylalanine? It's a dipeptide of a leucine and an alanine. The problem is, I haven't been able to find any really useful information on it. I could really use a diagram as well, if anyone can find or provide one!

GSS Syndrome[edit]

The GSS Syndrome article mentions a change in codon 102 from proline to leucine in the PRNP gene, but that is not mentioned in the article. Can someone add it? 20:45, 6 July 2007 (UTC)Reply[reply]

Needs nonpolar/neutral acidity specified.[edit]

Other amino acids have acidic/basic/neutral info, leucine is nonpolar and neutral, though I don't have a source handy for that. —Preceding unsigned comment added by (talk) 06:47, 24 March 2008 (UTC)Reply[reply]

Leucine hypoglycemia[edit]

Listening to a lecture by Dr. Russell Blaylock([1] at approx. 24 mins.) he mentions this condition as an acknowledged baby killer. Perhaps we could have some information here about this, perhaps even a dedicated article? __meco (talk) 09:28, 18 November 2008 (UTC)Reply[reply]

Blank sections[edit]

Dietary Aspects and Betaines are blank. Can someone please fill them in?-- (talk) 01:47, 27 April 2010 (UTC)Reply[reply]

What are the dietary sources?[edit]

Why are no foods listed? If this is an essential amino acid, then where do you get it? (talk) 05:40, 31 July 2011 (UTC)Reply[reply]

There is now a food table with animal-sourced and plant-sourced examples. With a few exceptions (gelatin) all protein contains leucine. In the United States, protein consumption averages 30-50% more than requirements, so shortfalls of any amino acids are rare. David notMD (talk) 09:06, 14 June 2017 (UTC)Reply[reply]

Where is whey?[edit]

Whey protein has about 10-12 grams per 100 grams and is notably missing from the list of foods from the department of agriculture reference (#9) I think the reference is quite misleading when there is a MUCH wider range of leucine content in the food supply.

See amino acid profile here: — Preceding unsigned comment added by (talk) 21:51, 25 May 2013 (UTC)Reply[reply]

Added to tableDavid notMD (talk) 09:23, 14 June 2017 (UTC)Reply[reply]

Dietary requirement for leucine[edit]

Information that can be incorporated into the article in some way: The U.S. Institute of Medicine set Recommended Dietary Allowances (RDAs) for protein as a whole and for individual amino acids. The adult RDA for protein is pegged to body weight, so it is 0.8 g/kg. For a 70 kg (154 lb) adult the RDA is 56 g/day. Average protein consumption, as determined by results from the last reported National Health And Nutrition Examination Survey (NHANES 2013-2014) is approximately 105 g/day for men ages 20-50 and 73 g/day for women in the same age range. Thus, on average, adult men and women consume more than the RDA for protein. The IOM has also established RDAs for individual amino acids. The RDAs for leucine is 42 mg/kg body weight. For the same example 70 kg person the leucine RDA is 2.9 g/day.

1. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein and Amino Acids. Institute of Medicine. National Academy Press. Pages 589-768 (2005). Accessed from:

2. What We Eat in America, NHANES 2013-2014: Nutrient Intakes from Food and Beverages: Mean Amounts Consumed per Individual, by Gender and Age. U.S. Department of Agriculture, Agricultural Research Service. 2016. Accessed from:

Leucine recommended intake added to article.David notMD (talk) 09:25, 14 June 2017 (UTC)Reply[reply]

External links modified[edit]

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Too much on HMB?[edit]

Considering HMB is a small fraction of what happens to leucine, there is way too much content on HMB here. HMB has its own article. David notMD (talk) 03:45, 13 June 2017 (UTC)Reply[reply]

On second thought, as the HMB pathways in the text are also in the metabolism figure, I am less inclined to try to delete HMB-related content. David notMD (talk) 15:42, 13 June 2017 (UTC)Reply[reply]
HMB is a more pharmacologically active substance than leucine and it's probably leucine's most potent metabolite w.r.t. effects on muscle protein metabolism. That by itself merits an entire level 3 subsection on that metabolite IMO, but I don't really feel like writing it. In any event, the reason it's mentioned so much in the Leucine#Metabolism in humans section is that the entire section was copy/pasted verbatim from the content in beta-Hydroxy beta-methylbutyric acid#Biosynthesis and beta-Hydroxy beta-methylbutyric acid#Metabolism. Seppi333 (Insert ) 22:13, 27 November 2017 (UTC)Reply[reply]

metabolism of leucine can be better[edit]

neither the text nor the picture tells in which compartment the reaction is going on ... which parts going on in the cytoplasm & which parts going on in the mitochondria

Yasir M. A. albayati — Preceding unsigned comment added by Yasir muhammed ali (talkcontribs) 19:28, 20 March 2018 (UTC)Reply[reply]

Wiki Education assignment: Advanced Writing Science[edit]

This article was the subject of a Wiki Education Foundation-supported course assignment, between 29 August 2022 and 16 December 2022. Further details are available on the course page. Student editor(s): Skol1214 (article contribs).

— Assignment last updated by Skol1214 (talk) 17:17, 29 November 2022 (UTC)Reply[reply]

Pronunciation: Loo-keen[edit]

Although many people pronounce this amino acid as "Loo-seen", the correct pronunciation is "Loo-keen".

The reason is that its name is derived from the greek word for white, being λευκός with a kappa. It's also preferential to pronounce it this way among the international chemistry and biology community to prevent confusion with Lysine, a quite different amino acid.

Same goes for Isoleucine. Please comment on this and if there is a quorum, I'll add it to the lemma.

Source: Auvideo (talk) 18:09, 16 March 2023 (UTC)Reply[reply]